Lesley Brown, who gave birth to the world's first test tube baby, paving the way for millions of women to become mothers, has died after a brief illness. She was 64.

Brown, who lived in Whitchurch, Bristol, made history in July 1978 when her daughter Louise was born at Oldham General Hospital.

Brown had been trying for a baby with her husband John for nine years before she became the first woman to give birth following IVF treatment.

She successfully conceived following pioneering treatment by Patrick Steptoe and Robert Edwards.

Louise Brown said: "Mum was a very quiet and private person who ended up in the world spotlight because she wanted a family so much.

"We are all missing her terribly."

She leaves behind daughters Louise and Natalie, who were both born following IVF treatment, her stepdaughter Sharon and five grandchildren.

Her husband died five years ago.

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