Health: Gene Decides Timing of Puberty
This study started when doctors in the reproductive endocrine unit at Massachusetts General Hospital carried out tests on a family from Saudi Arabia. A number of individuals in this family, both male and female, had failed to go through puberty. The scientists analysed blood taken from each member of the family. They found that the gene that codes for GPR54 was mutated in all those who had failed to reach puberty. It was fine in those who did not have the condition.
At the same time, scientists at the UK biotechnology company Paradigm Therapeutics contacted the US doctors to tell them they had bred mice that had failed to reach puberty. They had "knocked out" the gene for GPR54 in these mice. The scientists believe the gene makes a protein that helps to release the hormones that are responsible for the physical changes around puberty.
Both groups of scientists believe drugs could be developed to ensure this gene works properly and children can go through puberty normally. But they also believe it could help people with fertility problems and some types of cancer.
About one in 10,000 fail to go through puberty. Many others go through puberty too, some at just two years old. These hormonal changes can be disastrous when they strike a young child. If left to proceed unchecked, it could mean that growth is stunted as the body receives chemical signals telling it to switch off further height gain.
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