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The latest attempt to repeal the Obama-era healthcare act has failed after a dramatic night in the US Senate, reported BBC.
At least three Republicans - John McCain, Susan Collins and Lisa Murkowski - voted against the bill, which needed a simple majority to pass.
President Donald Trump said the three had "let the American people down".
The so-called "skinny" repeal, which would have scaled back some of the more controversial provisions, is the third failed attempt to repeal Obamacare.
It would have resulted in 16 million people losing their health insurance by 2026, with insurance premiums increasing by 20%, according to the Congressional Budget Office (CBO).
The vote was delayed after Senate Republicans kept a procedural vote open before the actual Obamacare vote while they attempted to persuade their members to vote for the repeal.
Vice President Mike Pence was seen talking to Mr McCain for more than 20 minutes. But Mr McCain then approached a group of Democrats, who appeared happy to see him.
The bill was eventually voted down by 51 votes to 49 in the Republican-dominated Senate.
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