Two people died and another three were seriously injured after a small plane crashed Tuesday into a home in Florida setting at least one more house on fire.

The victims are the machine's pilot and the other passenger on board.

A 10-year-old boy and his parents, who were in the house stricken have been hospitalised with heavy burns throughout their bodies.

The other child of the family, who is at the age of four, was declared missing after the accident.

The crash has probably occurred after smoke filled up the cockpit, local media reported.

The pilot of the twin-engine Cessna 310 signalised about the problem on the board of the aircraft but did not managed to land it the nearby Orlando-Sanford International Airport.

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