Arsenal and Manchester United will attempt to complete on Wednesday a clean sweep for English teams in the Champions League.
The two Premiership outfits will attempt to join Liverpool and Chelsea, who booked their own passage to the quarterfinal stage on Tuesday.
Arsenal lost 1-0 in their first match to Dutch club PSV, but received a welcome boost for the home return leg when captain Thierry Henry was declared fit to lead the line at Emirates Stadium.
Manchester United, playing also at home, have an easier task against Lille. The Premiership leaders won the first leg 1-0 on quick free kick taken by veteran Ryan Giggs, which sparked massive controversy in France and several appeals from the French club, but the continent's governing body UEFA rejected all of them.
Britain's fifth club left in the competition, Scottish champions Celtic travel to Italy to take on AC Milan, the first leg in Glasgow ending without goals.
The last match of the day pits two of the competition's most successful teams, which have fallen on harder times this season - Real Madrid and Bayern.
Both clubs languish in fourth place in their respective leagues, their chances for domestic success dwindling fast, and the Champions League remains the last hope of winning a major trophy this year.
The first leg of the tie, played at Madrid's Bernabeu stadium, ended in a 3-2 win for the hosts, but the two away goals scored by the German champions away from home mean a low-scoring win by one goal will put Bayern through on aggregate.