Half of the quarterfinal slots for this season's Champions League will be decided on Tuesday, headlined by the Liverpool-Barcelona match that pits the last two winners of the trophy.

Liverpool won the first leg at Barcelona's Camp Nou stadium two weeks ago 2-1, and even a 1-0 loss will suffice to ensure their progression to the next round of the competition.

Both teams have lost important championship matches at the weekend and will look for a morale-boosting win in Europe, but bookmakers are favouring Liverpool, who has a strong home record in all competitions this season.

Barcelona's chances are further damaged by the statistic that no club has successfully defended their trophy in the past decade.

In Tuesday's other three matches, Chelsea boss Jose Mourinho takes on his former club Porto in London. The English champions drew the first match in Portugal, 1-1.

Italian league leaders Internazionale will look to replicate their domestic top form away at Valencia, after failing to kill off the tie in the first meeting, which ended tied 2-2.

In the last match, five-time French champions Lyon will attempt to make it three consecutive seasons in the last eight of the competition. They host Italy's Roma after a scoreless first game in the Italian capital two weeks ago.

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