A fire described as the worst in Madrid's history has destroyed a skyscraper in the Spanish capital's financial district, causing no injuries, but part of it has reportedly collapsed.

More than 100 firefighters worked through the night in an attempt to extinguish the blaze in the city's eighth tallest building, the 32-storey Windsor Tower.

The fire has reportedly been caused by short circuit. "The fire is not under control," Madrid Mayor Alberto Ruiz Gallardon told reporters early on Sunday.

"We are all aware that we are fighting the biggest fire that the city of Madrid has had in its entire history," he said. "The fire department is making an extraordinary effort to stop the fire spreading to surrounding buildings," he said.

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