3 Scientists Share Nobel Prize in Medicine
Three cell biologists at American universities won the 2013 Nobel Prize in Physiology or Medicine on Monday for their work on how cells transport molecules.
James E. Rothman, Randy W. Schekman and Thomas C. Südhof, “have discovered the molecular principles that govern how this cargo is delivered to the right place at the right time in the cell,” according to a news release from the Nobel Foundation.
Randy Schekman discovered a set of genes that were required for vesicle traffic. James Rothman unravelled protein machinery that allows vesicles to fuse with their targets to permit transfer of cargo. Thomas Südhof revealed how signals instruct vesicles to release their cargo with precision.
“Through their discoveries, Rothman, Schekman and Südhof have revealed the exquisitely precise control system for the transport and delivery of cellular cargo. Disturbances in this system have deleterious effects and contribute to conditions such as neurological diseases, diabetes, and immunological disorders,” the Nobel Foundation.