Bolivian President Carlos Mesa announced Sunday he would submit his resignation on Monday in a nationally televised speech that came amid growing protests and frustration with his government. Mesa took office in October 2003, succeeding President Gonzalo Sanchez de Lozada, who resigned in the wake of bloody street protests that took the lives of at least 56 people. Mesa's government has struggled with a growing push for greater political autonomy in Bolivia's most prosperous region. In February, he shuffled his cabinet after massive street protests calling for regional autonomy and objecting to a planned increase in the price of fuel oil.

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